Sirolimus is a medicine that slows down your immune system so it does not reject a transplanted organ such as a kidney. It is also used without other medicines to treat a rare lung disorder called lymphangioleiomyomatosis (lim-FAN-gee-oh-LYE-oh-MYE-oh-ma-TOE-sis).
Oral sirolimus should be given once daily, as directed by your doctor, and preferably with food. It is also important to take it at the same time each day.
What is sirolimus?
Sirolimus is a drug that weakens your body’s immune system to help prevent it from rejecting a transplanted organ. It belongs to a group of drugs called immunosuppressants and is used in patients who have a kidney transplant.
The medication comes in tablet or liquid form, and you should take it daily, usually with or without food. It should be taken at the same time each day, and you should store the liquid in the refrigerator.
It is important to follow the medication guide given by your doctor or pharmacist. This will tell you what to do if you miss a dose, how long to wait before taking the next one, and any other instructions you need to follow.
You should also keep a list of all the medicines you take. This will help your doctor find out if any of them may interact with sirolimus.
Uses of sirolimus
Sirolimus is an immunosuppressant that is used to prevent kidney transplant rejection (when your body’s immune system attacks and kills your new kidney). It also is used in patients with a lung disease called lymphangioleiomyomatosis (LAM).
A study showed that the use of sirolimus in people with hepatocellular carcinoma who received a liver transplant improved their survival. They had better recurrence-free and overall survival rates in the first few years after their transplant.
The drug works by blocking an immune-system reaction that is caused by the presence of certain molecules in the body. It does this by inhibiting a process called the mTOR pathway.
This medication comes in tablets and liquid forms. It is taken once a day, either with or without food. The liquid form must be mixed with water or orange juice, and it should be kept refrigerated.
What is the mechanism of action of sirolimus?
Sirolimus is a drug that helps prevent the rejection of a kidney transplant. It works by suppressing your body’s immune system, which makes it less likely for it to attack a new kidney as a foreign substance that needs to be destroyed.
It also helps prevent your body from rejecting a lung transplant. This medication is usually taken daily, along with cyclosporine. You can take sirolimus with or without food, but you must use it exactly as your doctor instructs.
Your doctor may need to change the dose of sirolimus or stop it altogether if your transplant does not work as expected. You may need frequent medical tests to determine if sirolimus is working as it should.
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Sirolimus is a member of the class of drugs called immunosuppressants. It works by weakening the body’s immune system so that it can accept a transplanted kidney as if it were your own.
This medication is usually taken by mouth, once a day or as directed by your doctor. It should be taken at the same time each day to ensure that your body absorbs the correct amount of sirolimus.
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Is sirolimus used for cancer?
Sirolimus is used to treat cancer, especially non-small cell lung cancer (NSCLC). It also reduces the risk of rejection of a transplanted organ. It is given orally (by mouth) in tablets and solutions.
The medicine is usually taken once a day, either with or without food. Your doctor may adjust your dose during treatment, usually not more than once a week or every 14 days.
You should not take sirolimus if you have a history of skin cancer or a condition that causes overproduction of certain white blood cells. These conditions can cause cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure.
To prevent your body from producing too many white blood cells, you should use effective birth control to stop pregnancy while you are taking sirolimus and for at least 12 weeks after your last dose. Tell your doctor if you have any new skin lesions, low red blood cells (anemia), feeling sick or tired, difficulty breathing or chest pain, or cold hands and feet.
Sirolimus is given in a tablet or solution and is usually taken by mouth once a day. Your doctor may prescribe a lower dose or specific treatments to avoid side effects.
Storage
Sirolimus should be stored at room temperature and not in the refrigerator. Keep the bottles away from light and moisture (not in the bathroom).
The oral solution should be stored at room temperature for up to 15 days after opening. If a bottle appears to be hazy, let it sit at room temperature for a few minutes then gently shake it.
When handling sirolimus, wear appropriate gloves, eye/face protection, and a protective gown. Do not break or crush tablets/capsules to avoid releasing active sirolimus.
Precautions
When taking sirolimus, be sure to take it exactly as directed by your doctor. Do not miss a dose, even if it is close to the time of your next one.
Sirolimus tablets should be swallowed whole and not cut, crushed, chewed, or mixed with food. This will help keep a steady amount of the medication in your body and reduce stomach problems.
The oral liquid form of sirolimus should be stored in the refrigerator and not frozen. The liquid may develop a slight haze when stored at this temperature. This haze will disappear when the liquid reaches room temperature.
To use the oral liquid, insert a disposable amber oral syringe into an adapter provided with the bottle. Fully push down (depress) the plunger of the syringe. Once the syringe is inserted, tightly press down the plunger to withdraw the prescribed amount of sirolimus liquid into the syringe.
This medicine should be taken with water or orange juice. Store the syringe in the carrying case provided with the medication until you are ready to use it.
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